发明名称 |
STEROID DERIVATIVES FOR THE TREATMENT OF PROSTATIC HYPERTROPHY, THEIR PREPARATION AND USES |
摘要 |
<p>Compounds of formula (I): (see formula I) [wherein: R1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R2 is: aryl-substituted alkyl, aromatic heterocyclic- substituted alkyl or diarylamino; and R3 is carboxy or a group of formula -CONHSO2R4 wherein R4 is alkyl]; and pharmaceutically acceptable salts and esters thereof have valuable 5.alpha.-reductase inhibitory activity and can thus be used for the treatment and prophylaxis of, inter alia, prostatic hypertrophy as well as other disorders arising from excess levels of 5.alpha.-dihydro- testosterone.</p> |
申请公布号 |
CA2094300(A1) |
申请公布日期 |
1993.10.21 |
申请号 |
CA19932094300 |
申请日期 |
1993.04.19 |
申请人 |
KOJIMA, KOICHI;KURATA, HITOSHI;ISHIBASHI, KOKI;HAMADA, TAKAKAZU;HORIKOSHI, HIROYOSHI |
发明人 |
KOJIMA, KOICHI;KURATA, HITOSHI;ISHIBASHI, KOKI;HAMADA, TAKAKAZU;HORIKOSHI, HIROYOSHI |
分类号 |
C07J1/00;A61K;A61K31/56;A61K31/568;A61K31/575;A61P5/00;A61P13/02;A61P15/00;C07J;C07J41/00;C07J43/00;(IPC1-7):C07J41/00 |
主分类号 |
C07J1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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