发明名称 |
Transmucosal composition comprising a peptide and a cytidine derivative. |
摘要 |
<p>A transmucosal therapeutic composition comprising a physiologically active peptide or protein and a cytidine nucleotide derivative was produced. The above composition results in a satisfactory transmucosal absorption of physiologically active peptides or proteins which are otherwise hardly absorbed from the mucosa. Since it allows self-administration to the mucosa, such as the nasal, vaginal or digestive tract mucosa, in lieu of injection which causes pain, the invention is of great utility as a pharmaceutical dosage form for physiologically active peptides or proteins which must be administered over a protracted time. The preferred cytidine derivative is citicoline.</p> |
申请公布号 |
EP0566135(A1) |
申请公布日期 |
1993.10.20 |
申请号 |
EP19930106188 |
申请日期 |
1993.04.16 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
IGARI, YASUTAKA;YAMADA, MINORU;TAKETOMI, SHIGEHISA |
分类号 |
A61K9/00;A61K38/09;A61K38/21;A61K38/28;A61K38/29;A61K47/26;(IPC1-7):A61K47/18;A61K37/02;A61K37/24;A61K31/70 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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