| 摘要 |
4-19060/A Methanediphosphonic acid formulations with ion exchangers The invention relates to a novel advantageous oral dosage form for methanediphos-phonates, especially the active ingredient disodium pamidronate. A preferred dosage form comprises: a) disodium-3-amino-1-hydroxypropane-1,1-diphosphonate (disodium pamidronate), b) a cationic macroporous ion exchange resin based on a styrene/divinylbenzene copolymer having an exchangeable aminophosphonate group and, where appropriate, c) further pharmaceutically acceptable excipients. The ingredients can be processed to form tablets, dragées, capsules etc..
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