| 摘要 |
The degradation rates of bioerodible polymers used in sustained-release drug delivery formulations are regulated by the incorporation in the polymer of a regulating agent, or erosion rate modifier, which has substantially higher solubility in the polymer than in water. In polymers whose degradation rate is accelerated or decelerated by acids, bases or both, the erosion rate modifier is an acid or base with the appropriate solubility characteristics. Dissolving of an acid or base erosion rate modifier in the polymer as a solid solution permits the use of an acid or base of weaker strength than those used as erosion rate modifiers in the prior art, and achieves a more prolonged regulating effect on the polymer with a lesser potential for undesired injury to the polymer, to the drug, or to the tissues or the organism to which the formulation is applied. |
