INHIBITION OF P70 S6 KINASE

摘要

A method of screening for an antiproliferative or immunosuppressive agent, which method includes the steps of (1) contacting a eukaryotic cell with a candidate antiproliferative or immunosuppressive composition; and (2) determining the level of activity of a serine/threonine kinase or a serine/threonine phosphatase in the p70 S6 kinase cascade of said cell in the presence of the candidate composition, wherein a level of said activity that results in a lower p70 S6 kinase activity in the presence of the composition than in the absence of the composition is an indication that the composition is antiproliferative or immunosuppressive agent; and methods of treatment using such compositions.