| 摘要 |
2132744 9319788 PCTABS00027 Methods and diagnostic compositions are disclosed for enhancing magnetic resonance imaging which utilize a parmagnetic metal cluster. Magnetic resonance contrast media containing Z+¢Mn12X12(OYR)16(L)4!-, where OYR is an oxyacid such as benzoic acid, acetic acid, methyl sulphonic acid, methyl phosphonic acid; L is a neutral donor such as water, alcohol, pyridine, or other amines; X is a chalcogen, such as O or S; and Z is a pharmaceutically acceptable counterion are disclosed. Z may also be a paramagnetic counter ion, such as a high spin metal cluster. The paramagnetic cluster may optionally be complexed or conjugated to a carrier compound capable of altering the paramagnetic metal cluster's biodistribution, increasing its selectivity of tumor localization, and amplifying its proton relaxivity. |
