发明名称 |
Verfahren für Carbapenem-Zwischenprodukte. |
摘要 |
<p>A novel intermediate for synthesizing 1 beta -alkyl-1-carbapenem, i.e., 4 beta -(1 beta -alkyl-2-carboxyprop-2-enyl)azetidin-2-one ( II ), is prepared stereoselectively by treating 4-(leaving group substituted)azetidin-2-one ( I ) with trans-2-(leaving group substituted)methyl-3-alkylacrylic acid ( III ) and a reducing metal. <CHEM> wherein, R<1> is hydrogen, alkyl, or substituted alkyl; R<2> is optionally substituted alkyl; R<3> is hydrogen or a carboxy-protecting group; and R<4> and R<5> each is a leaving group.</p> |
申请公布号 |
DE68906945(T2) |
申请公布日期 |
1993.10.14 |
申请号 |
DE1989606945T |
申请日期 |
1989.03.13 |
申请人 |
SHIONOGI SEIYAKU K.K., OSAKA, JP |
发明人 |
UYEO, SHOICHIRO, NAKAGYO-KU KYOTO-SHI KYOTO, JP |
分类号 |
C07D205/08;C07D477/04;C07F7/18;(IPC1-7):C07D205/08;C07D487/04;A61K31/40 |
主分类号 |
C07D205/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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