摘要 |
<p>Novel cyclohexane-ylidene derivatives of formula (I) are described herein. These compounds inhibit PDEIV or the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; these compounds are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase IV.</p> |