| 发明名称 |
METHOD OF TREATING CLOSTRIDIUM DIFFICILE COLITIS AND CHOLERA |
| 摘要 |
The invention relates to the treatment of antibiotic associated colitis, typically due to Clostridium difficile using Platelet Activating Factor antogonists, such as WEB 2170, SR 27417 or BN 52021, or the cyclooxygenase antagonists, such as indomethacin. The PAF antagonists BN 52021 and SR 27417 and the cyclooxygenase antagonist indomethacin were effective in inhibiting the secretory effects caused by C. difficile Toxin A and even by Cholera toxin. |
| 申请公布号 |
WO9319745(A1) |
申请公布日期 |
1993.10.14 |
| 申请号 |
WO1993US03026 |
申请日期 |
1993.04.01 |
| 申请人 |
THE UNIVERSITY OF VIRGINIA PATENTS FOUNDATION |
发明人 |
GUERRANT, RICHARD, L.;GUODONG, FANG;FONTELES, MANASSES, C. |
| 分类号 |
A61K31/00;A61K31/12;A61K31/335;A61K31/34;A61K31/365;A61K31/405;A61K31/44;A61K31/4439;A61K31/47;A61K31/55;A61K31/551;(IPC1-7):A61K31/12;A61K31/40 |
主分类号 |
A61K31/00 |
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