| 发明名称 |
SPECIFIC DETECTION OF CELL SURFACE RECEPTOR LEUKOCYTE ADHESION MOLECULE-1 |
| 摘要 |
A shed form of leukocyte adhesion molecule-1 (LAM-1, L-selectin) is present in high levels in human plasma. Quantitative methods of detecting shed LAM-1 (sLAM-1) by Western blot and ELISA analysis are disclosed. Also disclosed are methods for the specific detection of cell-surface bound LAM-1 in the presence of shed LAM-1 and for immunotherapy using monoclonal antibodies reactive with cell-surface bound LAM-1 but not reactive with shed LAM-1. |
| 申请公布号 |
WO9319782(A1) |
申请公布日期 |
1993.10.14 |
| 申请号 |
WO1993US02705 |
申请日期 |
1993.03.24 |
| 申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
TEDDER, THOMAS, F.;SCHLEIFFENBAUM, BORIS;SPERTINI, OLIVIER |
| 分类号 |
G01N33/53;A61K38/00;A61K38/17;A61K39/395;A61K49/00;A61P29/00;A61P35/02;C07K14/705;C07K14/715;C07K16/00;C07K16/28;C12N5/06;C12N5/10;C12N5/20;C12N15/02;C12N15/09;C12P21/04;C12P21/08;C12Q1/04;C12R1/91;G01N33/50;G01N33/569;G01N33/577;(IPC1-7):A61K39/395;G01N33/543;C07K15/28;G01N33/536;G01N33/566 |
主分类号 |
G01N33/53 |
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