发明名称 1,4 NAPHTHOQUINONE DERIVATIVES WITH ANTI-PROTOZOAL AND ANTI-PARASITIC ACTIVITY
摘要 2133744 9320044 PCTABS00027 Compounds of general formula (II) wherein R3 is C1-35 hydrocarbyl group optionally substituted by one to five substituents, selected from halo, C1-6alkoxy, hydroxy, amino, and mono- or di-C1-4alkyl-amino; and either the dotted line represents a double bond between the 2 and 3 positions of the naphthyl ring; R1 and R4 each represent = O; and R2 represents a group (a) wherein n is 2 or 3, R6 and R7 which may be the same or different, each represent a hydrogen atom, a C1-6alkyl group, optionally substituted by hydroxy, C1-6alkoxy or a group (b) wherein R9 is a C1-6alkyl group optionally substituted by an amino group optionally substituted by one or two alkyl groups, or R6 and R7 may each be a group (c) wherein R8 is a C1-6alkyl group, A is an oxygen atom or a group (d) wherein R5 represents a hydrogen atom, a C1-6alkyl group optionally substituted by hydroxy, C1-6 alkoxy or an amino group optionally substituted by one or two C1-6alkyl groups or R5 is a group (e) wherein R10 is a C1-6alkyl group or R5 is a group (f) wherein p is 2 or 3 and R11 and R12 are as hereinbefore defined for R6 and R7 or, when m is 1 and n is 2 R5 may be linked to R6 so that (g) forms a piperazine ring; or the dotted line represents double bonds between the 1, 2 and 3, 4 positions of the naphthyl ring, and R1, R2 and R4 each represent a group (h) (wherein n, A, R6 and R7 are as hereinbefore defined); and physiologically acceptable salts thereof.
申请公布号 CA2133744(A1) 申请公布日期 1993.10.14
申请号 CA19932133744 申请日期 1993.04.05
申请人 WELLCOME FOUND 发明人 HUDSON ALAN T;YEATES CLIVE L
分类号 A61K31/265;A61K31/27;A61P33/00;A61P33/02;A61P33/10;C07C219/16;C07C269/04;C07C271/34;C07D295/205;(IPC1-7):C07C271/34;C07D295/215;A61K31/495 主分类号 A61K31/265
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