METHODS AND COMPOSITIONS FOR GENE, TUMOR, AND VIRAL INFECTION THERAPY, AND PREVENTION OF PROGRAMMED CELL DEATH (APOPTOSIS)

摘要

The present invention relates to methods of treatment of programmed cell death (apoptosis) through the use of the HSV-1 gene gamma 134.5 or the product of its expression, ICP34.5. The gene and its expression have been demonstrated to be required for HSV-1 neurovirulence, and in particular, to act as an inhibitor of neuronal programmed cell death which allows for viral replication. Use of the gene therapy, or the protein itself, can be expected to result in inhibition of programmed cell death in various neurodegenerative diseases. This invention also relates to novel vectors for gene therapy, including modified herpes virus. Methods are presented for conducting assays for substances capable of mimicing, potentiating or inhibiting the expression of gamma 134.5 or the activity of ICP34.5. Also, methods are disclosed for the treatment of tumorogenic diseases, including cancer, and for treatment of herpes and other viral infections using inhibitors of gamma 134.5 expression or ICP34.5 activity.