发明名称 |
PEPTIDES OF AN ANTIGEN, CAPABLE OF RECOGNITION BY OR INDUCTION OF CYTOTOXIC T LYMPHOCYTES, AND METHOD OF THEIR IDENTIFICATION |
摘要 |
A method of identifying peptides of an antigen of interest which are capable of recognition by or induction of cytotoxic T lymphocytes, comprises the steps of: ascertaining a "motif" of peptides which bind to a chosen HLA class I allele; providing peptides having this motif which are present in the known sequence of the antigen of interest; screening the peptides using an HLA assembly assay; and screening the resulting peptides for recognition by or induction of cytotoxic T lymphocytes. The above peptides have been identified by this method, and the peptides and vaccines containing them are also claimed. |
申请公布号 |
WO9320103(A2) |
申请公布日期 |
1993.10.14 |
申请号 |
WO1993GB00711 |
申请日期 |
1993.04.05 |
申请人 |
ISIS INNOVATION LIMITED |
发明人 |
HILL, ADRIAN, VIVIAN, SINTON;GOTCH, FRANCES, MARGARET;ELVIN, JOHN;MCMICHAEL, ANDREW, JAMES;WHITTLE, HILTON, CARTER |
分类号 |
A61K39/00;A61P33/06;C07K14/155;C07K14/445 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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