发明名称 |
NON-INFECTIOUS HIV PARTICLES AND USES THEREFOR |
摘要 |
This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described. |
申请公布号 |
WO9320220(A1) |
申请公布日期 |
1993.10.14 |
申请号 |
WO1993US02142 |
申请日期 |
1993.03.10 |
申请人 |
WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH |
发明人 |
ALDOVINI, ANNA;YOUNG, RICHARD, A.;FEINBERG, MARK, B.;TRONO, DIDIER;BALTIMORE, DAVID |
分类号 |
G01N33/569;A61K39/00;A61K39/21;A61P31/12;C07K14/155;C07K14/16;C12N5/00;C12N5/10;C12N7/04;C12N15/09;C12N15/867;C12R1/91;C12R1/92;(IPC1-7):C12N15/86;C12N15/39;G01N33/50 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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