Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes

摘要

This invention relates to compounds having the formula I: <IMAGE> I wherein R1 is H, F or MeO, which are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.