| 摘要 |
PURPOSE:To provide the compound having an excellent cardiac action and useful as a cardiac agent for improving cardiac failure itself. CONSTITUTION:An acylated gingerol compound of formula I [R is acyl; Y is CH2-CH(OH), CH=CH; n is 0-10], for example, 5-hydroxy-1-(3'-methoxy-4'- toluoyloxyphenyl)dodecan-3-one. The compound is obtained e.g. by acylating a natural gingerol compound of formula II (n is 4, 6, 8) contained in ginger with an acylating agent comprising an acyl halide such as acetyl chloride in a solvent such as pyridine at -10 deg.C to the refluxing temperature of the solution. In the reaction, the acylating agent is employed in an amount of the equivalent mole to 25 times moles that of the compound of formula II. |
