摘要 |
<p>5-Deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acid derivatives of formula <CHEM> wherein Z is O or S; R<1> is H or the same carboxyl protecting group; R<2> is H or an amino protecting group; and the configuration about the carbon atom designate * is L; useful for treating susceptible neoplasms in mammals.</p> |