发明名称 |
Acetohydroxamic compound and complexes pharmaceutical compositions containing them and processes of preparation and use |
摘要 |
An acetohydroxamic acid compound of formula I <IMAGE> as such or in form of a complex with beta -cyclodextrin or hydroxypropyl- beta -cyclodextrin specifically inhibits 5-lipoxygenase and is useful in pharmaceutical compositions for prophylaxis and treatment of diseases due to the action of leucotrienes. The acetohydroxamic acid compound may be prepared by reacting 3-thiophenecarboxaldehyde with hydroxylamine or a salt thereof to form the corresponding oxime, reducing the oxime with a boron-containing reducing agent to form N-(thien-3-yl)methyl-hydroxylamine, and introducing an acetyl group.
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申请公布号 |
US5252562(A) |
申请公布日期 |
1993.10.12 |
申请号 |
US19920911623 |
申请日期 |
1992.07.10 |
申请人 |
GRUENENTHAL GMBH |
发明人 |
SEIPP, ULRICH;ENGLBERGER, WERNER;HAURAND, MICHAEL;SCHNEIDER, JOHANNES |
分类号 |
A61K31/38;A61K31/715;C07D333/20;C08B37/00;C08B37/16;(IPC1-7):A61K31/70;C07D33/70 |
主分类号 |
A61K31/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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