FOERBAETTRING AV ETT FOERFARANDE FOER FRAMSTAELLNING AV ETT KARBAPENEMDERIVAT GENOM ATT AVLAEGSNA ALLYLESTERSKYDDSGRUPP FRAON KARBAPENEMDERIVAT

摘要

A process is disclosed for the deprotection of allylic esters and ethers. The process comprises reacting an allyl ester of a carboxylic acid or an allyl ether of a phenol with pyrrolidine or piperidine and a catalytic amount of an organic-soluble palladium complex having a coordinating phosphine ligand to cleave the allyl moiety. The resultant carboxylic acid or phenol is then recovered.