摘要 |
<p>PURPOSE:To resolute an optically active amino acid derivative, etc., from a racemic compound by mixing a specific 1, 1'-binaphthyl-2, 2'-bis(carboxyamido) derivative in the derivative as a stationary component. CONSTITUTION:The 1, 1'-binaphtyl-2, 2'-bis(carboxyamido) derivative expressed by the expression is mixed in the title column filler as a stationary component. In the expression, the 1, 1'-binaphthyl-2, 2'-diyl residue indicates an optically active substance having the conformation of an (S)- or (R)-isomer. In addition, the R1 and R4 can be made the same or different from each other and represent hydrogen atoms, methyl group, or ethyl, group. The R2 and R3 can also be made the same or different from each other and represent alkyl or aralkyl group of >=C6. However, such a case is excluded that both the R1 and R4 are hydrogen atoms and both the R2 and R3 are n-decyl groups. Since the optically active compound is used, an excellent effect is obtained in the optical resolution of an enantiomer pair, especially, racemic modification, etc.</p> |