Amino sugar derivatives.

摘要

A compound represented by formula (I): <CHEM> wherein R<1> represents -CO-Z<1>-N(Z<1><1>)-CO-Z<2>-H or -CO-Z<3>-H, wherein Z<1>, Z<2>, and Z<3> each represent an alkylene group having from 1 to 20 carbon atoms, a phenylene group, or a combination thereof, and Z<1><1> represents a hydrogen atom, an alkyl group having from 1 to 20 carbon atoms which may be substituted with a phenyl group, a phenyl group which may be substituted with an alkyl group having from 1 to 20 carbon atoms, or an alkylene group having from 1 to 20 carbon atoms which may contain therein a phenylene group; R<2> represents -CO-Z<4>-N(Z<1><2>)-CO-Z<5>-H, -CO-Z<6>-H or a hydrogen atom, wherein Z<4>, Z<5>, and Z<6> each have the same meaning as Z<1>, and Z<1><2> has the same meaning as Z<1><1>; Q<1> and Q<2> each represent a carboxyl group or a phosphonoxy group; Q<3> represents a hydrogen atom, a carboxyl group or a phosphonoxy group; m represents 0 or an integer of from 1 to 20; n represents 0 or an integer of from 1 to 20; Y<1> represents an alkylene group having from 1 to 10 carbon atoms which may contain one or more substituents selected from -OCOR<1><1> and -NHCOR<1><2>, wherein R<1><1> represents -Z<1><3> or -Z<7>-N(Z<1><4>)-CO-Z<8>-H (wherein Z<7> and Z<8> each have the same meaning as Z<1>, and Z<1><3> and Z<1><4> each have the same meaning as Z<1><1>) and R<1><2> represents -Z<1><5> or -Z<9>-N(Z<1><6>)-CO-Z<1><0>-H (wherein Z<9> and Z<1><0> each have the same meaning as Z<1>, and Z<1><5> and Z<1><6> each have the same meaning as Z<1><1>), and a salt thereof. The compound inhibits TNF derivation by endotoxin and is therefore useful for the treatment of multiorganic insufficiencies.