| 摘要 |
PCT No. PCT/GB86/00540 Sec. 371 Date Jun. 30, 1987 Sec. 102(e) Date Jun. 30, 1987 PCT Filed Sep. 11, 1986 PCT Pub. No. WO87/01594 PCT Pub. Date Mar. 26, 1987.A polysaccharide chemically joined to a nitroxyl spin label (NSL) compound has use for the preparation of an NMR diagnostic composition. An agent for modifying H2O relaxation times in NMR diagnosis may comprise a polysaccharide to which is chemically linked both an NSL compound and an organic complexing agent to which is complexed a paramagnetic metal ion, such as Gd(III) or Cu(II). Polysaccharides include dextran, starch and cellulose. The preferred NSL compound is 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl.
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