发明名称 |
2'-deoxy-5-substituted uridine derivatives |
摘要 |
Novel 2'-deoxy-5-substituted uridine derivative represented by the general formula, <IMAGE> wherein R1 is a hydrogen atom, a benzoyl group or a tetrahydrofuranyl group; R2 is a fluorine atom or a trifluoromethyl group; and any one of R3 and R4 is a hydrogen atom and the other one is an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a benzyl group having as the substituents selected from the group consisting of a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms and a nitro group, or an alkyl group having 1 to 3 carbon atoms having one or two phenyl groups as the substituents. The novel 2'-deoxy-5-substituteduridine derivative possesses excellent antitumor activity with less toxicity, thus it is useful as antitumor agent.
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申请公布号 |
US5250673(A) |
申请公布日期 |
1993.10.05 |
申请号 |
US19890422721 |
申请日期 |
1989.10.17 |
申请人 |
TAIHO PHARMACEUTICAL COMPANY, LTD. |
发明人 |
FUJII, SETSURO;YAMASHITA, JUN-ICHI;MATSUMOTO, HIROSHI;TAKEDA, SETSUO;TERADA, TADAFUMI;YASUMOTO, MITSUGI;UNEMI, NORIO |
分类号 |
C07H19/06;(IPC1-7):C07H19/073 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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