| 摘要 |
PURPOSE:To obtain an optically active cyclic amine in stereoselectively high yield by reacting an ethylenediamine derivative or an ethanol-amine derivative with a specific compound in the presence of a catalyst comprising a specific palladium complex. CONSTITUTION:A compound (e.g. N,N'-dimethylethylenediamine) of formula I (R<1> is benzyl, benzoyl, etc.; X is O or NR<1>) is reacted with a compound [e.g. (Z)-2-butene-1,4-diylbis(methylcarbonate) of formula II (R<2> is l-4C alkyl) in an inert organic solvent (e.g. benzene) in the presence of a palladium complex coordinated with an optically active phosphine to give the objective compound. The complex is preferably obtained by reacting a zero-valent or bivalent Pd compound with an optically active phosphine in an inert solvent. Tri(dibenzylideneacetone)(chloroform) dipalladium (O) is preferable as the zero- valent Pd compound. |
