| 摘要 |
PURPOSE:To obtain a fluoroaniline useful as an intermediate for functional chemicals such as pharmaceuticals and agricultural chemicals in high yield from a chlorofluorobenzene which has become easily available owing to the recent establishment of an industrial production process. CONSTITUTION:The fluoroaniline of formula II can be produced in high yield by reacting 1mol of a chlorofluorobenzene of formula I with usually 1-300mol (preferably 5-100mol) of ammonia at 100-300 deg.C (preferably 150-270 deg.C) in the presence of usually 0.1-50mol%, preferably 1-30mol% (in terms of copper based on the compound of formula I) of a copper-based catalyst such as metallic copper, copper oxide, copper hydroxide, cuprous or cupric salt of inorganic or organic acid or copper halide, preferably copper chloride, copper acetate, copper oxide or copper cyanide, thereby selectively ammonolyzing the chlorine atom. |
