| 摘要 |
A method is provided for mutating a first nucleic acid sequence encoding a first peptide or protein molecule into a second nucleic acid sequence encoding a second peptide or protein molecule, which second peptide or protein molecule is capable of binding to or catalytically binding to a recognition sequence. Also provided is a host cell for use in said method, wherein the host cell permits identification of the second peptide or protein molecule, and said host cell expresses a fusion protein comprising a growth factor, the recognition sequence, and optionally a modulation moiety. In a preferred embodiment, the second peptide or protein molecule has an activity selected from the group consisting of isomerization, addition, substitution, synthesis, fragmentation, phosphorylation, dephosphorylation, hydroxylation, adenylation, deadenylation, stereoisomerisation, methylation, uridenylation, glycosylation, and deglycosylation. <IMAGE> |
