PROCESS FOR THE PRODUCTION OF (+) BIOTIN

摘要

PROCESS FOR THE PRODUCTION OF (+) BIOTIN Process for the production of (+) biotin. The process comprises catalytically hydrogenating a compound of the formula: I with hydrogen, separating the desired diastereomer of the formula: II introducing a protective group, converting the diastereomer by further reaction with a thiocarboxylic acid salt derivative into the corresponding thiolactone by a Grignard reaction and subsequently splitting off of water or a compound of the formula: (C6H5)3p?(CH2)4COOR3.X? III 58 in the presence of a base to a compound of the formula: IV catalytically hydrogenating the compound and then cleaving the protective groups to form (I) biotin. The process starts from a readily-available intermediate product and employs relatively few industrially-feasible step. 59