发明名称 |
A DNA TRANSPORTER SYSTEM AND METHOD OF USE |
摘要 |
2131620 9318759 PCTABS00025 A DNA transporter system capable of non-covalently binding to DNA and facilitating the insertion of the DNA into a cell. The DNA transporter system includes a binding complex which non-covalently binds the DNA. The binding complex includes a molecule that is capable of non-covalently binding to the DNA and being covalently linked to a surface ligand and to a nuclear ligand. The surface ligand is capable of binding to a cell surface receptor and the nuclear ligand is capable of recognizing and transporting the transporter system through the nuclear membrane. A plurality of these binding complexes are attached to the DNA to facilitate the transport of the DNA into the cell. Additionally, a third binding complex which includes a virus can also be non-covalently linked to the DNA. The virus facilitates the movement of the DNA through the cytoplasm and into the nucleus. Also described are a variety of structures which can be used as part of the transporter system as well as methods of using the transporter system to introduce DNA into cells. |
申请公布号 |
CA2131620(A1) |
申请公布日期 |
1993.09.30 |
申请号 |
CA19932131620 |
申请日期 |
1993.03.19 |
申请人 |
BAYLOR COLLEGE MEDICINE |
发明人 |
SMITH LOUIS C;WOO SAVIO L C |
分类号 |
C12N15/09;A61K38/00;A61K47/48;A61K48/00;C07H21/04;C07K7/02;C07K14/00;C07K14/11;C07K14/775;C12M1/00;C12N15/87 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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