| 摘要 |
New pharmacologically active derivatives of N-(2-mercapto-acetyl) homocysteine, both in its cyclised gamma -thiolactonic form or in the open chain form are described, such derivatives having formula (I) wherein R represents a hydrogen atom, a C1-3 alkyl, a C7-9 aralkyl or a group COR1 in which R1 is a C1-3 alkyl or a C7-9 aralkyl, the aralkyl groups being unsubstituted or substituted on the phenyl ring by one or more halogens, C1-3 alkyl or C1-3 alkoxy; L is hydrogen, Q is hydroxy, or L and Q, together, form a bond. The process for the preparation of the above compounds as well as the pharmaceutical compositions containing them are also described. The above compounds are potent free-radical scavenging agents. They can prevent the cellular damage induced by free radicals and they have additional local antiinflammatory, mucolytic and mucokinetic activities. Therefore, the compounds may be useful in the treatment of acute and chronic bronchitis, emphysema, acute and chronic ORL pathologies, as antidotes against drug-induced depletion of endogenous glutathione and in case of alteration of the biological oxidant-antioxidant balance. |
