3-UREIDO SUBSTITUTED BENZODIAZEPIN-2-ONES HAVING CHOLECYSTOKININ AND/OR GASTRIN ANTAGONISTIC ACTIVITY AND THEIR USE IN THERAPY

摘要

Compounds of formula (I), and salts and prodrugs thereof. In that said formula, R1 represents certain optionally substitued alkyl or C¿3-7?cycloalkyl; R2 represents (II) or (III), where m is 0, 1, 2 or 3, R?9¿ is H or C¿1-6?alkyl, R?10¿ is imidazolyl, triazolyl or tetrazolyl, and R11 is H, C¿1-6?alkyl or halo; R?3¿ is C¿1-6?alkyl, halo or NR?6R7; R4¿ is C¿1-7?alkyl, C3-10cycloalkyl, C3-10cycloalkylC1-4alkyl, C6-10bicycloalkyl, optionally substituted aryl, or NR?12R13; R5¿ is H or C¿1-4?alkyl; n is 0, 1, 2 or 3; are CCK and/or gastrin antagonists useful in therapy.