| 摘要 |
2132868 9319167 PCTABS00025 The invention provides a method of lysing malignant cells, which comprises contacting the malignant cells with an antibody which specifically reacts with an epitope present on the beta subunit of human chorionic gonadotropin and/or beta subunit fragment, under conditions such that the malignant cells lyse. This invention further provides a method of quantitatively measuring malignant cells or a method of obtaining an enriched population of malignant cells, which comprises contacting live malignant cells to be measured or contacting a population of cells comprising live malignant cells with an antibody directed to an epitope of human chorionic gonadotropin, its subunits and/or subunit fragments, under conditions such that the antibody is capable of forming a complex with the epitope if present on the cell surface, and detecting the presence of any complex formed using fluorescence activated cell sorting technology, the presence of such complex on the surface of the cells indicating that the cells are malignant, and isolating the cells which form a complex with the antibody.
|
