发明名称 |
eta <6> METAL COMPLEXES OF 4-ARYL-1,4-DIHYDROPYRIDINES |
摘要 |
The present invention is directed to eta <6> metal complexes of the arene group of 4-aryl-1,4-dihydropyridines. The 4-aryl-1,4-dihydropyridines are made according to the Hantzsch pyridine synthesis, and are then reacted with a pi acid ligand-metal reagent to attach the metal in an eta <6> fashion to the 6 pi electrons of the arene ring. The 4-aryl-1,4-dihydropyridine metal complexes are designed to provide useful spectroscopic information concerning the conformation of the 4-aryl-1,4-dihydropyridines and how such compounds interact with the calcium channel protein. Moreover, the 4-aryl-1,4-dihydropyridine metal complexes are robust calcium antagonists and compare to or exceed the biological activity of previously known calcium channel antagonists. |
申请公布号 |
WO9319076(A1) |
申请公布日期 |
1993.09.30 |
申请号 |
WO1993US02682 |
申请日期 |
1993.03.19 |
申请人 |
IDAHO RESEARCH FOUNDATION, INC. |
发明人 |
NATALE, NICHOLAS, R.;BITTERWOLF, THOMAS, E.;HUBLER, TIMOTHY |
分类号 |
C07F11/00;C07F17/00 |
主分类号 |
C07F11/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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