发明名称 |
2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents |
摘要 |
The present invention is novel compounds which are 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.
|
申请公布号 |
US5248682(A) |
申请公布日期 |
1993.09.28 |
申请号 |
US19920924713 |
申请日期 |
1992.08.03 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
CONNOR, DAVID T.;KOSTLAN, CATHERINE R. |
分类号 |
C07D239/34;C07D263/32;C07D401/04;C07D401/06;C07D403/06;C07D413/06;C07D417/06 |
主分类号 |
C07D239/34 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|