Sterile entry/exit total containment process for closed systems using plastic tubes

摘要

A process for sterile entry/exit into a closed system permits safe addition of reagent/nutrient/process modules, etc., removal of biological samples or depleted process modules such as filters, etc. all without exposing the operator to possibly dangerous materials such as blood and without endangering the contents of the system such as in cell-culturing. A novel welder and process is disclosed to illustrate the process.