Racemic separation of 7 alpha -acyloxy-6 beta -hydroxymethyl-2-oxabicyclo[3.3.0]-octan-3-ones by stereospecific enzymatic acylate hydrolysis

摘要

PCT No. PCT/DE87/00520 Sec. 371 Date Jul. 13, 1988 Sec. 102(e) Date Jul. 13, 1988 PCT Filed Nov. 12, 1987 PCT Pub. No. WO88/03570 PCT Pub. Date May 19, 1988.The invention relates to a process for the production of optically active (-)-oxabicyclo[3.3.0]octanolones of formula (-)-I (-)-I wherein R is defined herein, comprising subjecting a racemic mixture of oxabicyclo[3.3.0]octanolone acylate to stereospecific acylate hydrolysis and separating the resultant products.