CRYSTALLINE FORMS OF ENDO-2,3-DIHYDRO-N-(8-METHYL-8-AZABICYCLO-[3.2.1.] OCT-3-YL)-2-OXO-1H-BENZIMIDAZOLE-1-CARBOXAMIDE HYDROCHLORIDE MONOHYDRATE AND OF ENDO-3 ETHYL-2,3-DIHYDRO-N-(8-METHYL-8-AZABICYCLO[3.2.1.]OCT-3 -YL)- 2-OXO-1H-BENZIMIDAZOLE-1-CARBOXAMIDE HYDROCHLORIDE MONOHYDRATE

摘要

Crystalline monohydrates of azabicyclo-1H-benzimidazole-1-carboxamides, the preparation and use thereof Crystalline monohydrates of endo-2,3-dihydro-N-(8-methyl-8-azabicyclo¢3.2.1!oct-3-yl)-2-oxo-1H-benzimida-zole-1-carboxamide hydrochloride and of endo-3-ethyl-2,3-dihydro-N-(8-methyl-8-azabicyclo¢3.2.1!oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride of formula . HCI.H20 (Compound 2a: R = H) (Compound 2b: R - C2H5) the processes for their preparation and pharmaceutical compositions containing them.