| 摘要 |
O- and N-Glycopeptide derivatives of the formula I <IMAGE> in which aromatic is benzene, naphthalene, chroman, chromene or coumarone radical, a is 1 to 5, b is 0 to 4, c is 0 or 1, d is 1 or 2, R<1> is H or (C1-C3)-alkyl, R<2> is H, (C1-C3)-alkyl or (C1-C3)-alkoxy, R<3> is H, OH, (C1-C3)-alkyloxy, NH2, NH-(C1-C6)-alkanoyl, NH-benzoyl, NH-SO3H or NH-acyl radical of a natural N-acetylated amino acid, R<4> is H, OH or (C1-C3)-alkyloxy, R<5> is H, OH, (C1-C3)-alkyloxy, fluorine, chlorine or bromine, R<6> is H, CH3, CH2OH, CH2O-(C1-C6)-alkanoyl, CH2NHCOCH3 or CH2NH-SO3H R<5> and R<6> together are O-CH2-O-CH2, O-CH(CH3)-O-CH2 or O-C(CH3)2-O-CH2, R<7> is hydroxy-(C2-C4)-alkyl or (C2-C4)-alkyloxy-(C2-C4)-alkyl, R<8> is H or (C1-C6)-alkyl or R<7>-N-R<8> together form a pyrrolidine, piperidine or morpholine ring which can be substituted by HO, HOCH2, CH3 or COOH, W is -O-, -CONH- or -C6H4CONH- and H-X is HCl, (C1-C7)-alkanoic acid or a physiologically tolerated inorganic or organic acid, processes for their preparation and a pharmaceutical composition which contains these compounds are described. These pharmaceuticals can be used in particular for the therapy of thrombotic disorders. |
