| 摘要 |
<p>Alkylenebis(dioxopiperazine) derivatives of formula (I) and their salts are new. In (I), R1 is lower alkyl (esp. methyl); R2 is H or -CH2OCOR3; R3 is lower alkyl or (opt. substd.) phenyl, furyl or styryl (pref. the substituents on phenyl, furyl or styryl are halogen, lower alkyl, lower alkoxy, nitro, amino or cyano), or -(CH2)nR4 or -CHPhNR5R6 or -OR7; R4 is carboxyl, (opt. substd.) phenyl, (opt. substd.) phenoxy (where the substituents on phenyl or phenoxy are pref. halogen, lower alkyl, lower alkoxy, nitro, amino or cyano); R5 and R6 are H or amino-protective groups, pref. acetyl, tert-butoxycarbonyl or benzyloxycarbonyl; R7 is lower alkyl, or benzyl (opt. substd. by halogen, lower alkyl, lower alkoxy, nitro, cyano or amino, pref. halo or nitro); n is 1 or 2. Specifically, R1 is methyl and R3 is lower alkyl (e.g. methyl), phenyl, halophenyl, lower alkylphenyl (e.g. m-tolyl), furyl, styryl, halostyryl, benzyl, halobenzyl (e.g. 2-chlorobenzyl), phenoxymethyl, (di)halophenoxymethyl (e.g. 2,4-dichlorophenoxymethyl), lower alkoxy (e.g. methoxy or isobutoxy), benzyloxy, halobenzyloxy or nitrobenzyloxy (e.g. 4-nitrobenzyloxy). Compounds (I) are pref. the meso or erythro isomer.</p> |
