| 摘要 |
The present invention discloses compounds of the formula wherein X is C or N; Y is C or N; R11 is hydrogen, hydroxy, or alkoxy; R12 and R13 are each independently hydrogen; halogen; CF3; CN; OH; alkyl; cycloalkyl; cycloalkylalkyl; alkenyl; alkynyl; alkoxy; phenylalkyl; amino; nitro; sulphamoyl; pipiridyl; pyrrolidinyl; acyl; CO2H; CO2-alkyl; CO-amino; NH-CO-alkyl; phenylsulphonyl which may be substituted with halogen, CF3, CN, OH, alkyl, alkenyl, alkynyl, alkoxy, amino, or nitro; phenyloxy which may be substituted with halogen, CF3, CN, OH, alkyl, alkenyl, alkynyl, alkoxy, amino, or nitro; phenylamino which may be substituted with halogen, CF3, CN, OH, alkyl, alkenyl, alkynyl, alkoxy, amino, or nitro; or aryl which may be substituted one or more times with halogen, CF3, CN, OH, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, phenoxy, phenylalkyl, amino, nitro, sulphamoyl, pipiridyl, pyrrolidinyl, CO2H, CO2-alkyl, CO-amino, or NH-CO-alkyl; and R4, R5, R6 and R7 are each independently hydrogen; halogen; amino; nitro; CN; CF3; COOH; COO-alkyl; alkyl; acyl; alkoxy; -(CH2)n,-OH wherein n is 0, 1,2, or 3; -(CH2)m-O-alkyl wherein m is 0, 1,2, or 3; -(CH2)0-O-acyl wherein o is 0, 1,2, or 3; and that if X is N then R4 is absent and that if Y is N then R7 is absent; or a pharmaceutically-acceptable addition salt thereof 48 The compounds are useful as pharmaceuticals, for example, in the treatment of stroke, ischemia, anoxia, migraine and psychosis.
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