| 摘要 |
Compounds of formula (Ia), (Ib) or (Ic): <CHEM> <CHEM> <CHEM> in which: X is H or halogen; Y is H, halogen, alkyl, or optionally substituted amino; Z is COOH or 5-tetrazolyl; Q is N or C having a substituent R<2>, and R<2> is H, halogen, or optionally substituted alkoxy or alkyl; W is O or S; T is optionally substituted alkylene or alkenylene; R<1> is H, alkenyl, alkynyl, amino, cycloalkyl, alkoxy, aryl, an aromatic heteromonocycle, a fused aromatic group or alkyl, said groups, other than H, optionally being substituted; or R<1> and R<2> may together represent a group of formula (f): <CHEM> wherein A is H or optionally substituted alkyl; G is N or =CH; G<1> is methylene, =CO, O, S or optionally substituted amino; and p = 0 or 1; R represents a group of formula (h) or (i): <CHEM> <CHEM> where R<3> and R<6> are optionally substituted and each is aryl, an aromatic heteromonocyclic group, or a fused aromatic group; R<4>, R<5> and R<7> are each H or alkyl; R<8> is H, alkyl, -OH or alkoxy; n and n' are each 1 or 2; m = 0 or 1 and n'' = 1, 2, 3 or 4; and pharmaceutically acceptable salts and esters thereof, have useful anti-HIV activity, and can be used in therapy. |
