Occlusive, elastomeric backing materials in transdermal drug delivery systems, and associated methods of manufacture and use

摘要

Improved transdermal drug delivery systems are provided which contain an occlusive, elastomeric backing layer which is preferably liquid-resistant. The systems contain as a backing layer a single homogeneous sheet of an elastomeric material having a moisture vapor transmission rate ("MVTR") in the range of about 0.1 to 20 g/m2/hr and a Young's modulus in the range of about 104 to 109 dynes/cm2. Methods for making and using transdermal drug delivery devices containing such backing layers are provided as well.