Substituted benzazepines useful as intermediates for producing pharmaceutically active compounds

摘要

Disclosed herein are novel compounds of formula II <IMAGE> II and pharmaceutically acceptable salts thereof, wherein: Q represents H, halo or -OSO2R'' wherein R'' is CH3, CF3, phenyl or tolyl; R3a represents H, alkyl, allyl, cyclopropylmethyl or COOR14 wherein R14 is alkyl, aryl, aralkyl or haloalkyl; R4 represents H, halo, alkyl, haloalkyl or alkoxy; R5a represents -OR10, -N(R9)2, -O-C(R7)2xOCOR13, or alkoxy; wherein each R9 independently represents H, alkyl, alkoxy, alkoxyalkyl, aralkyl or aryl; R10 represents H, -COR9 or -CON(R9)2; and R13 represents alkyl, aralkyl or aryl, with the proviso that R3a can not be hydrogen or alkyl when Q is hydrogen, R4 is hydrogen, and R5a is hydroxy. Compounds of formula II are useful intermediates for producing compounds having valuable pharmaceutical properties in treating psychosis, depression, pain and hypertension.