发明名称 |
N,N'-distubstituted guanidines and their use as excitatory amino acid antagonists |
摘要 |
N,N'-disubstituted guanidines exhibiting a high binding affinity to phencyclidine (PCP) receptors are disclosed. These N,N'-disubstituted guanidine derivatives act as non-competitive inhibitors or glutamate-induced responses generated via the NMDA receptor by acting as blockers for the ion channel of the NMDA receptor-ion channel complex. These compounds thus exert a neuroprotective property and are useful in the therapeutic treatment of neuronal loss in hypoxia, brain or spinal cord ischemia, brain or spinal cord trauma, as well as being useful for the treatment of epilepsy, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Down's Syndrome, Korsakoff's disease and other neurodegenerative disorders. |
申请公布号 |
ZA9301288(B) |
申请公布日期 |
1993.09.20 |
申请号 |
ZA19930001288 |
申请日期 |
1993.02.24 |
申请人 |
STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY;UNIVERSITY OF OREGON, EUGEN, OREGON |
发明人 |
ECKARD WEBER;JOHN F W KEANA |
分类号 |
C07D215/40;A01N37/52;A61K31/155;A61K31/365;A61K31/37;A61K31/47;A61P25/00;A61P25/28;C07C279/18;C07D311/18 |
主分类号 |
C07D215/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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