Covalent cross-linkages for two oligonucleotide strands or for first and second regions of a single oligonucleotide strand connect sugar moieties of nucleotides on the respective strands or the regions of the single strand. The cross-linkages are connected to at least one strand or region via a space-spanning group. The cross-linkage also can be connected to the other strand or other region via a space-spanning group or via an abasic site located on the other strand or other region.
申请公布号
WO9318052(A1)
申请公布日期
1993.09.16
申请号
WO1993US02059
申请日期
1993.03.05
申请人
ISIS PHARMACEUTICALS, INC.
发明人
COOK, PHILLIP, DAN;MANOHARAN, MUTHIAN;BRUICE, THOMAS