BENZIMIDAZOLE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS

摘要

The object compound of formula (I) wherein R<1> is hydrogen, halogen, nitro, lower alkyl, lower alkoxy, amino or acylamino, R<2>, R<3> and R<4> are each hydrogen, halogen, nitro, cyano, lower alkyl, lower alkenyl, lower alkylthio, mono or di or trihalo(lower)alkyl, oxo(lower)alkyl, hydroxy(lower)alkyl or optionally esterified carboxy; or R<2> and R<3> are linked together to form 1,3-butadienylene, R<5> is hydrogen or imino-protective group, R<6> is lower alkyl, R<7> is nitro, optionally esterified or amidated carboxy or optionally substituted amino, A is lower alkylen, Q is CH or N, X is N or CH, Y is NH, O or S, and Z is S, SO2 or 0, and pharmaceutically acceptable salts thereof which are useful as a medicament.