| 摘要 |
<p>A method for preparing β-phenylisoserine and analogues thereof having general formula (I) from an aromatic aldehyde and an α-methylarylamine-S, and through a lactam of general formula (II). In formulae (I) and (II), Ar is an aryl radical, Ph is an optionally substituted phenyl radical, R1 is an ester or ether alcohol function protective grouping, and R is a hydrogen atom or an alkyl radical optionally substituted by a phenyl radical. The acids of general formula (I) (R = H) may be used to prepare taxane derivatives having remarkable antitumoral and antileukaemic activity.</p> |
