发明名称 |
IMIDAZOLE, TRIAZOLE AND TETRAZOLE DERIVATIVES |
摘要 |
A class of substituted imidazole, triazole and tetrazole derivatives of formula (I), wherein the broken circle represents two non-adjacent double bonds in any position in the five-membered ring; two, three or four of V,W,X,Y and Z represent nitrogen and the remainder represent carbon provided that, when two of V,W,X,Y and Z represent nitrogen and the remainder represent carbon, then the said nitrogen atoms are in non-adjacent positions within the five-membered ring; E represents a bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms; F represents a group of formula (II); U represents nitrogen or C-R<2>; B represents oxygen, sulphur or N-R<3>; are selective agonists of 5-HT1-like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated. |
申请公布号 |
WO9318029(A1) |
申请公布日期 |
1993.09.16 |
申请号 |
WO1993GB00474 |
申请日期 |
1993.03.05 |
申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
MATASSA, VICTOR, GIULIO;REEVE, AUSTIN, JOHN;ROUTLEDGE, HELEN;STERNFELD, FRANCINE;STREET, LESLIE, JOSEPH |
分类号 |
A61K31/41;A61K31/4178;A61K31/4196;A61P25/04;A61P25/06;C07D403/14;C07D521/00 |
主分类号 |
A61K31/41 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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