发明名称 |
NEW ANTICOAGULANT PEPTIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS WELL AS A PROCESS FOR THE PREPARATION THEREOF |
摘要 |
This invention relates to new peptide derivatives of the general formula (I): A-Xaa-Arg-H, wherein A represents a D- or L-isochroman-1-carbonyl, D- or L-isochroman-3-carbonyl group, furthermore an acyl group of the general formula: D- or DL-A'-CH(OH)-CO, wherein A' represents a phenyl, benzyl, 1-naphthyl, 1-naphthylmethyl, 2-naphthyl, 2-naphthylmethyl, 9-fluorenyl, benzhydryl, cyclohexyl, cyclohexylmethyl, 2-pyridyl, 3-pyridyl or 4-pyridyl group, and Xaa represents an L-prolyl or an L-pipecolinic acid residue, and Arg stands for an L-arginine residue, their acid addition salts formed with an organic or inorganic acid and pharmaceutical compositions containing the same. Furthermore the invention relates to a process for preparing them. The compounds of the invention have valuable therapeutic, particularly anticoagulant, properties. |
申请公布号 |
WO9318060(A1) |
申请公布日期 |
1993.09.16 |
申请号 |
WO1993HU00013 |
申请日期 |
1993.03.04 |
申请人 |
GYOGYSZERKUTATO INTEZET KFT. |
发明人 |
BAJUSZ, SANDOR;BAGDY, DANIEL;BARABAS, EVA;FEHER, ANDRAS;SZABO, GABRIELLA;SZELL, GYOERGYNE;VEGHELYI, BELANE;HORVATH, GYULA;JUHASZ, ATTILA;LAVICH, JANOSNE;MOHAI, LASZLONE;MORAVCSIK, IMRE;SZEKER, GABORNE;PALLAGI, ISTVAN;PALNE-ARNYOSI, KATALIN |
分类号 |
A61K38/00;A61P7/02;C07D207/16;C07D211/60;C07D405/06;C07K1/06;C07K5/06;C07K5/078 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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