摘要 |
A process for the production of optimally stable, orally administrable solution forms of medicaments containing high- molecular polysaccharides, with controlled release of drugs having beta-blocking action, consists of reacting 1 to 20 parts (w/w) of beta-blocking agent (e.g. oxprenolol, pindolol, sotalol, metoprolol, alprenolol, acebutolol, antenolol, bopindolol, practolol, nadolol, or propranolol) in 100 parts of an aqueous solution with 0.001 to 10.0 parts of a polysaccharide, e.g. Xanthan Gum having beta-1,4-glucan chain, or dextran, or amylodextrin, or carboxymethylamylum. The reaction is allowed to take place in the course of 20 minutes at a pH adjusted to 2.0 - 4.5, with vigorous stirring at 80 DEG C temperature. Following the usual method of the pharmaceutical practice, the system is then formulated by the addition of water to obtain a solution suitable for oral administration. |