Antiherpes peptide derivatives having a ureido N-terminus.

摘要

Disclosed herein are peptide derivatives of the formula A-B-NHCH{CH2C(O)R<1>}C(O)-NHCH{CR<2>(R<3>)COOH}C(O)-D wherein A is a terminal group, for example, an alkylaminocarbonyl or a phenylalkylaminocarbonyl; B is an amino acid residue; R<1> is alkyl, cycloalkyl or a disubsubstituted amino; R<2> is hydrogen or alkyl and R<3> is alkyl, or R<2> is hydrogen and R<3> is phenylalkyl, or R<2> and R<3> are joined to form a cycloalkyl; and D is a terminal unit, for example, an alkylamino or a monovalent amino acid radical such as NHCH(alkyl)C(O)OH. The derivatives are useful for treating herpes infections.